Senolytics: Clearing Senescent ‘Zombie’ Cells for Systemic Tissue Renewal
As cells accumulate DNA damage, telomere shortening, or metabolic stress, they enter a state called cellular senescence. Instead of undergoing programmed cell death (apoptosis), these non-dividing “zombie cells” remain active and secretes toxic compounds into surrounding tissues. ### The Senescence-Associated Secretory Phenotype (SASP) Senescent cells release a destructive cocktail known as the SASP, containing pro-inflammatory … Read more